Chan et al. showed that, in hepatocellular carcinoma cells, IL6-activated JAK1 phosphorylates PDL1 at tyrosine Y112, which enhances the association of PDL1 with endoplasmic reticulum-associated (ER-associated) N-glycosyltransferase isoform STT3A [79]. Here, CD274 is linked to hepatocellular carcinoma.