For instance, Chen et al.27 reported that circHIPK3 depletion significantly induced autophagy via miR-124-3p-STAT3-PRKAA/AMPKa axis and there was an antagonistic regulation on autophagy between circHIPK3 and linear HIPK3. Du WW et al.28 showed that the oncogenic circDnmt1-stimulated autophagy flux in breast carcinoma via interaction with both p53 and AUF1. This evidence concerns the gene HIPK3 and breast carcinoma.