The results presented above suggest that, for the population or confirmed patients whose nucleic acid test results are negative but whose performance is similar to that of the patients with COVID-19, patient age, the presence of complications, a significant decline in lymphocytes, a significant increase in the ESR, and a significant increase in CRP levels can be used to predict the risk of short-term death and strengthen management, rationally distribute medical materials, and reduce the conversion rate and death rate of patients with critical diseases. This evidence concerns the gene CRP and COVID-19.