CD274 and head and neck squamous cell carcinoma: The observation that the subgroup of HNSCC patients with an absent early hypoxia response and tumoral PD-L1 expression exhibited the worst prognosis regarding LRC and PFS is in line with a recently proposed hypoxia-transcriptional classifier that identified 3 patient subgroups with different hypoxia-immune phenotypes: A hypoxialow/immunehigh, a hypoxiahigh/immunelow and a mixed phenotype 35.