In line with the Kaplan-Meier analyses, Cox analyses revealed no difference regarding LRC (HR = 0.734, 95% CI 0.311 - 1.731, p = 0.480), PFS (HR = 0.813, 95% CI 0.377 - 1.752, p = 0.597) and OS (HR = 0.698, 95% CI 0.299 - 1.629, p = 0.405) for HNSCC patients with increased pre-therapeutic PD-L1 expression on intratumoral immune cells. This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.