Therefore, silencing of MED13L reduced recruitment of P300 to chromatin, diminished global H3K27ac modification, inhibited activities of enhancer and/or promoters as well as decreased expression of multiple oncogenes, especially PRKCA. Strikingly, knocking-down of PRKCA could evidently improve NSCLC radiosensitivity (Figure 7). The gene discussed is MED13L; the disease is non-small cell lung carcinoma.