For instance, when MED8 (head), MED1 (middle) and MED23 (tail) proteins were immunoprecipitated, the amount of co-immunoprecipitated MED12, CCNC or CDK8 protein (the kinase module) was considerably reduced or almost absent in NSCLC cells after silencing of MED13L. Here, CDK8 is linked to non-small cell lung carcinoma.