Considering that the specific and potent chemical antagonists and agonists are still not available 36, SWELL1 siRNA was able to significantly reduce the levels of cellular triglyceride and cholesterol in HepG2 cells, HepG2.2.15 cells and esophageal cancer cell line K180 (Figure 3E-F and Figure S3A), implying that SWELL1 may broadly lead to abnormal lipid metabolism in cancers. This evidence concerns the gene LRRC8A and esophageal cancer.