RSAD2 and infection: As compared with polyI:C, AiV induced a lower level of antiviral gene expression, with huge differences in the level of IFNβ, Viperin, RIG-I, MDA5, IFN induced protein with tetratricopeptide repeats 3 (IFIT3) and CXCL10 between AiV infection and polyI:C stimulation (Figure 1B).