Although the abnormal expression of several glycolytic genes, including phosphoglycerate kinase 1 (PGK1), lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1) 22 as well as glycogen phosphorylases PYGL 23 and gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) 17 have been reported in ccRCC, the underlying molecular mechanism of glycogen deregulation remains elusive. Here, PDK1 is linked to nonpapillary renal cell carcinoma.