AKT1 and atherosclerosis: As shown in Figure 5, the PI3K-Akt signaling pathway shows the highest number of target connections (degree = 15), followed by the MAPK signaling pathway (degree = 13), neuroactive ligand-receptor interaction (degree = 12), fluid shear stress and atherosclerosis (degree = 11), nonalcoholic fatty liver disease (NAFLD) (degree = 11), and Ras signaling pathway (degree = 11).