Our study confirms that ginseng (with main components including total ginsenoside and ginseng polysaccharide) is a rational and alternative strategy to treat lung adenocarcinoma, and upregulated JUN, IL-1β, IL-2, ICAM1, HMOX1, MMP9, and MMP2 targets and downregulated PTGS2 and TNF genes may be predictably important targets related to cell proliferation/apoptosis/migration and poor prognosis of cancer for ginseng treatment of lung adenocarcinoma. Here, TNF is linked to lung adenocarcinoma.