Probiotics can also prevent some kind of cancers specially colon cancer through different ways, including: enhancing the mucus barrier, up regulation of immunoglobulins such as IgA, down regulation of inflammatory cytokines, creating an unfavorable environment through secretion of antimicrobial factors such as bacteriocin, NO, defensing and H2O2. The gene discussed is CD79A; the disease is malignant colon neoplasm.