Systemic activation of cholecystokinin-GABA neurons by clozapine-N-oxide in triple transgenic cholecystokinin-GABA/hM3Dq mice, in which about 22% of GABAergic neurons in the hippocampus and 19% in the prefrontal cortex are cholecystokinin-GABA neurons, not only enhanced contextual fear conditioning/discrimination, social/object recognition, and puzzle box performance, but also enhanced anxiety in the elevated plus maze [62]. This evidence concerns the gene CCK and Anxiety.