CCN2 and metastatic malignant neoplasm in the lymph nodes: Jiang et al. also demonstrated that high CCN2 expression is correlated with increased lymph node metastasis, enhanced peritoneal dissemination, and short five-year survival [60]; these findings are also consistent with the expression of CTGF in GSE33651 and Oncomine GC datasets, indicating a proliferation-promoting role of CTGF in cancer.