THBS1 expression has been correlated with tumor angiogenesis, tumor growth, and metastasis [46]In GC, THBS1 may play a proangiogenic and proinflammatory role due to its positive correlation with vascular endothelial growth factor (VEGF), and elevated THBS1 expression levels have been related to tumor growth and lymph node metastasis in GC [47, 48]. This evidence concerns the gene VEGFA and neoplasm.