Additional significant pathways were also of particular interest such as IL-8 signaling (6th ranked pathways in terms of significant), the neuroprotective role of THOP1 in Alzheimer's disease (13th), IL-10 signaling (17th), and role of IL-17A in Arthritis (18th) because of their involvement in brain disorders and inflammatory/immune response. The gene discussed is THOP1; the disease is early-onset autosomal dominant Alzheimer disease.