Of note that among the genes included in this signature, some have already been involved in the development of clinical forms of malaria, and either encode for proteins of erythrocytic surface membrane ANK1 and GYPC (Table 1) or for inflammatory/immune components CXCL10, CCL2, CXCR2, VWA1, CD177, IL1R2, ARG1, IL2RA, and CXCL2 (Figure 1(a), Table 1). The gene discussed is IL1R2; the disease is malaria.