With the results from lignin, Kwiecien et al.(26) proved the efficacy of pentoxifylline, an inhibitor of TNF-α activity against WIRS-induced gastric lesions, the efficacy of olive leaf extract,(27) and prickly pear cactus,(28) in which commonly significant scavenging action of free radicals was noted.(29) Among several searches for ideal agent to mitigate SRMD, we reached to apply NKM 23-1 based on preliminary exploration that NKM 23-1 significantly reduced the severity of HCl-induced gastric ulcer and ethanol-associated damages (data not shown). This evidence concerns the gene TNF and gastric ulcer.