For example, dietary supplementation with quercetin prevented HF diet-induced hyperglycemia after 8-weeks feeding.(34) Isoquercitrin ameliorated hyperglycemia and regulated the key enzymes for glucose metabolism in diabetic rats.(35) Similarly, the anti-hyperglycemic effect was also observed after oral administration of rutin (50 mg/kg body weight).(36) As to the mechanism for anti-hyperglycemia in this study, GLUT4 translocation in the skeletal muscle was involved in the downstream event for AMPK phosphorylation (Fig. 3) without activating insulin- and JAK/STAT-pathways (data not shown). The gene discussed is SLC2A4; the disease is hydrops fetalis.