SREBF1 and hydrops fetalis: ACC is a well-known target for AMPK and phosphorylation of ACC leads to inhibit its activity and decrease the content of malonyl-CoA, resulting an increase in the CPT-1 activity through cancelling the inhibitory effect of malonyl-CoA against CPT-1.(42,43) In addition, quercetin and its glycosides suppressed HF diet-increased SREBP1 and FAS expression (Fig. 4 and 5).