TNF and allergic disease: Antigen binds to the cell-associated IgE and triggers degranulation of the mast cells or basophils, causing the release of their allergy-producing mediators and also the sustained synthesis and release of certain cytokines, chemokines and growth factors.(4) Tumor necrosis factor (TNF)-α is one of the multifunctional cytokines that mediates various inflammation-promoting biologic activities.(5) Thus, the inhibitors of degranulation or TNF-α production in activated mast cells and basophils are possible to be a candidate for anti-allergic food ingredient.