GLP1R and Hyperglycemia: Recently, much attention has been paid to the health beneficial functions of polyphenols and polyphenol-rich food materials.(14) Prevention of hyperglycemia by polyphenols by promoting translocation of GLUT4 through the activation of AMPK signaling pathway in the muscle cells is well documented.(15,16) Of these, procyanidin has a unique mechanism for promotion of GLUT4 translocation, because it activates insulin signaling pathway through secretion of GLP-1, in addition to the activation of AMPK pathway.