Cacao liquor procyanidin (CLPr), which is an extract from cacao liquor containing (+)-catechin, (–)-epicatechin and procyanidins abundantly, prevents hyperglycemia by stimulating glucose uptake and glucose transporter type 4 translocation through AMP-activated protein kinase (AMPK) pathway in muscle cells.(25,26) CLPr increases energy metabolism and prevents obesity and hyperglycemia through AMPK pathway.(26) Moreover, CLPr activates enteroendocrine GLP-1/insulin pathway to reduce the postprandial hyperglycemia. The gene discussed is GCG; the disease is Hyperglycemia.