For example, resveratrol affects the circadian rhythms by changing the phase shift of Bmal1. (18,19) Nobiletin protects against insulin resistance and disorders of lipid metabolism through regulation of Bmal1 expression in hepatocytes.(45) The same report demonstrated that nobiletin regulates not only expression of Bmal1 but also phosphorylation of AMPK. The gene discussed is BMAL1; the disease is Insulin resistance.