CEBPA and obesity due to melanocortin 4 receptor deficiency: It is reported that C/EBPα knockout mice revealed significant reduction of hepatic triglyceride level by down-regulating liypogenic genes despite obesity.(12) In 3T3-L1 cells, AMPK activator, AICAR, reduced the expression of C/EBPα,(44) suggesting activation of AMPK downregulates the expression of C/EBPα.