TGFB1 and Hepatic fibrosis: We then adopted a CCl4-induced liver fibrosis model in which downregulation of TGF-β1 can ameliorate liver fibrosis.19–21 As shown in Fig. 6a, mice were intraperitoneally injected with CCl4 twice per week for four weeks in combination with daily oral administration of miR2911; in comparison, intravenous (IV) injection of miR2911 was performed as a positive control to “bypass” dietary miRNA absorption via the GI tract.