Our previous study showed that Galectin-3 plays an important role in HCC progression.21 In the present study, we constructed a large-scale model of HCC by increasing the number of cases to 278 (training set, n = 278) and obtaining an HCC tissue microarray consisting of a further 90 cases (testing set, n = 90) for validation. Here, LGALS3 is linked to hepatocellular carcinoma.