In addition, the expression level of nuclear β-catenin also showed a positive association with that of IGFBP3 and vimentin in all three HCC sets (Fig. 6h, i; Supplementary Fig. 14e, f), suggesting the probably direct regulation of β-catenin on IGFBP3 and vimentin in vivo. Here, IGFBP3 is linked to hepatocellular carcinoma.