LGALS3 and neoplasm: Intracellular Galectin-3 regulates signalling pathways by interacting with cytoplasmic and nuclear proteins.17 Accumulating evidences suggested that β-catenin signalling was responsible for tumour angiogenesis and EMT induced by aberrant protein expression.24–26 Furthermore, the GSEA results indicated that Galectin-3 had a significantly positive association with the Wnt signalling pathway (Supplementary Fig. 6), and genes positively associated with Galectin-3 expression in this set were shown in Supplementary Table S1.