For in vivo test, an EphB4-overexpressing SMMC-7721 (EphB4+/7721) cell line was established (Figs. 2e and S1c) and the anti-tumor effect of HHT on xenograft model of wild type SMMC-7721 (7721) cells and EphB4+/7721 cells was investigated. Here, EPHB4 is linked to hereditary hemorrhagic telangiectasia.