Dip G-induced GABARAPL1 expression was reversed by knocking down ERβ, while silencing GABARAPL1 showed no effect on the upregulation of ERβ by Dip G. It is thus likely that Dip G induces basal-like breast cancer cell differentiation via an ERβ-dependent induction of GABARAPL1. Here, ESR2 is linked to breast cancer.