MYC and cancer: Accordingly, Dip G reduced the percentage of CD44+ CD24− cells and downregulated the canonical Wnt/β-catenin signaling pathway known to regulate the self-renewal and stemness of cancer cells, as evidenced by the increase in the levels of p-β-catenin (Ser33/37/Thr41) and p-β-catenin (Thr41/Ser45) and the decrease in the levels of p-β-catenin (Ser552), p-β-catenin (Ser675) and c-Myc in both MDA-MB-231 and SUM1315 cells (Fig. S3).