CHMP2B and amyotrophic lateral sclerosis: Other mutations in CHMP2B have been identified in FTD and ALS patients (Cannon et al., 2006; Cox et al., 2010; Ferrari et al., 2010; Ghanim et al., 2010; Momeni et al., 2006; Parkinson et al., 2006; Rizzu et al., 2006; van Blitterswijk et al., 2012; van der Zee et al., 2008) and similar endosomal disruptions have been observed in associated patient tissue and rat primary neurons expressing these CHMP2B mutations (Cox et al., 2010; Han et al., 2012; Lee et al., 2007).