Associations between CSF pTau/Aβ40 and tau PET were stronger in ROIs in the temporal lobe than other areas such as frontal and occipital lobes that accumulate tau in later stages of disease [53, 54], consistent with our observation and recent studies [14, 15, 55] that CSF tauopathy is an early marker of tau pathology. The gene discussed is MAPT; the disease is tauopathy.