Baseline Aβ PET (Fig. 6a, βstd = − 0.41 [95% CI, − 0.59, − 0.23]), CSF pTau/Aβ40 (Fig. 6b, βstd = − 0.53 [95% CI, − 0.69, − 0.36]), and Temporal-metaROI tau PET (Fig. 6c, βstd = − 0.73 [95% CI, − 0.86, − 0.60]) were all associated with subsequent cognitive decline in Aβ+ participants (Fig. 6), whereas only tau PET (βstd = − 0.68[95% CI, − 0.87, − 0.48], p <  0.001) remained predictive when all variables were added into one multivariate model. This evidence concerns the gene MAPT and Mental deterioration.