Autophagy also plays a role in clearing aggregated forms of TDP-43 and is linked to ALS through mutations in autophagy-related proteins SQSTM1, TANK Binding Kinase 1 (TBK1) and Optineurin (OPTN) [87, 113, 124–128]. The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.