TARDBP and amyotrophic lateral sclerosis: ALS-causing mutations however rarely reside within these motifs (with the exceptions of A90V in the NLS, and mutations between amino acids 294-300 in M5), and TDP-43 mislocalization exists outside of TARDBP mutations, suggesting extrinsic factors from TDP-43 govern its subcellular localization [4, 6, 28, 151, 211–222].