SOD1 and amyotrophic lateral sclerosis: This pathological phenomena is considered a hallmark of ALS as it is observed in approximately 97% of all ALS patients regardless of the mechanisms of disease onset, with the notable exceptions of familial ALS (fALS) caused by mutations in Zn/Cu Superoxide Dismutase 1 (SOD1) and Fused in Sarcoma (FUS) [1, 10–15].