CTF35 and CTF25 can be generated through proteolytic cleavage via Caspases 3 and 7 after asparagine-89, and Caspase 4 after asparagine-174, respectively, and caspase activity is also modulated by the ALS-linked protein Progranulin (PGRN) [63–69]. Here, GRN is linked to amyotrophic lateral sclerosis.