As many of the truncated species of TDP-43 are of similar molecular weights many studies simply nest them as “CTF35” or “CTF25” based on molecular weight without investigation to the exact species observed which may limit the understanding of TDP-43 species contribution to ALS as different species display distinctive properties [59, 63, 74, 75]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.