TARDBP and amyotrophic lateral sclerosis: TDP-43 aggregates in ALS also accumulate full length and lower molecular weight species of TDP-43 and stain positive for the ALS-linked ubiquitin-binding autophagic adaptor Sequestosome 1 (SQSTM1, also known as p62) [8, 55–60, 82, 86–89].