Subgroup analyses showed the baseline level of plasma angiopoietin-1 was median 736.6 pg/mL (IQR 496.5–1177.7, range 303.7–1839.7) in stage III and IV cancer and 1299.0 pg/mL (IQR 1224.2–1844.0, range 402.4–2400.7) in stage I and II cancer (Mann-Whitney U test, p = 0.1439). The gene discussed is ANGPT1; the disease is cancer.