The plasma level of angiopoietin-2 was lower in cancer patients compared to controls, median 1362.9 pg/mL (IQR 1223.1–1707.7, range 750.4–2054.2) vs. 1868.5 (IQR 1531.0–2338.4, range 1248.7–5489.9) (Mann-Whitney U test, p = 0.0257; Shapiro-Wilk test, p < 0.0001; Kolmogorov-Smirnov test, p < 0.0100). This evidence concerns the gene ANGPT2 and cancer.