In the univariable analysis, both AIP ≥ 0.11 (Hazard ratio (HR) 3.391, 95% confidence interval (CI) 1.075, 10.695, P = 0.037) and CRP (HR 1.008, 95% CI 1.001, 1.016, P = 0.035) were significantly associated with CVA during follow-up. The gene discussed is CRP; the disease is autoimmune pancreatitis.