The MSAs include anti-EJ (glycyl) and anti-PL-7(threonyl) antibodies [1] Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is one of the non-antisynthetase MSAs, which uniquely presents as clinically-amyopathic dermatomyositis (CADM), with its well-known potentially fatal course due to rapidly progressive ILD [2]. The gene discussed is IFIH1; the disease is dermatomyositis.