S1PR1 was a determinant of immune infiltration in BRCA (tumor purity; r = − 0.508, P = 1.76e-66), including subtypes of BRCA (BRCA-Basal: r = − 0.5411, P = 1.28e-06; BRCA-Her2: r = − 0.505, P = 4.44e-06 and BRCA-Luminal: r = − 0.557, P = 9.15e-46). This evidence concerns the gene ERBB2 and neoplasm.