LY-294002 isan inhibitor of PI3Ks including AMH which is also involved insex differentiation and the cyclic AMP pathway, an interacting pathway of PI3Ks80 and has been shown to be biologically active in GC cell lines.81 Testosterone depletion is used as a therapy in prostate cancer but hasnot been explored in GC. The gene discussed is AMH; the disease is Familial prostate cancer.