PKIB function has not been explored within theliterature in regard to GC but has been shown to promote proliferation throughPI3K/AKT pathway in breast cancer.59POU2AF1 is another gene that has not been characterized withinthe GC literature but has been found to be a high-risk gene in gastrointestinalstromal tumors, a type of soft tissue sarcoma and rheumatoid arthritis.60,61 Again, the mixed subtype is molecularly different from the intestinal anddiffuse gastric subtypes based on this genetic pathway analysis with notablyless involvement of metabolism related genes. The gene discussed is PKIB; the disease is rheumatoid arthritis.