CACNA1C and Cognitive impairment: The role of the Cav1.2 isoform of L-type Ca2+ channels (LTCCs) is well known in hippocampal-mediated long-term memory and related behaviors [1–5].The clinical relevance of this relationship is bolstered by the fact thatCACNA1 C, the gene that encodesCav1.2, is a prominent risk gene for a wide array of neuropsychiatric [2,3,6,7]andneurodegenerative [8–11]disorders that manifest with cognitive impairment.