In GM‐CSF‐cultured BMDCs, a heterogeneous population of macrophages and DCs,68 Blimp‐1 directly represses Il‐6 and Ccl2. 54Dysregulation of IL‐6 expression by DCs in vivo was also described in the context of inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE) studies, where CD11c+ cell‐specific Blimp‐1 deficiency led to enhanced immunopathology. This evidence concerns the gene ITGAX and inflammatory bowel disease.