Although it is unknown whether these DNA-methylations are mechanistically linked to epigenetic histone modifications such as the H3K27ac enhancer marker, our hMADS cell data allow us to speculate that type 2 diabetes-associated GPS2 alterations trigger a massive epigenetic remodeling of this histone marker in human adipocytes in the context of type 2 diabetes, including at the ABCG1 locus. The gene discussed is GPS2; the disease is type 2 diabetes mellitus.