Our db/db mouse model results revealed that the macrophage infiltration, increased inflammatory responses, and immune system dysregulation in the liver tissues, is in agreement with the experimental observations by Elinav et al,30 Ni et al,31 and Onodera et al.32Therefore, it seems reasonable to conjecture that adiponectin exerted beneficial effects toward the reduction of inflammation and dysregulation during the immune response in the NASH development. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.