NEFL and Parkinson disease: Supplementary Table e1 shows the baseline values of CSF NfL and clinical scores. Among the 176 participants, patients with OND had the highest baseline median CSF NfL at 839 pg/mL, followed by PD patients (562 pg/mL) and HCs (494 pg/mL), P = 0.01 (Fig. 1a). Linear mixed-effects model of log2NfL on CSF NfL diagnoses, time, and their interactions did not show significant differences across the groups in this small sample set (Supplementary Table e2).