Considering that aroused inflammatory response was one of the phenotypes of cardiac hypertrophy, we subsequently detected total and phosphorylated IKKα, IκBα and p65 in NF‐κB axis, and transcriptional levels of pro‐inflammatory cytokines in WT and USP19‐KO mice with or without TAC intervention. This evidence concerns the gene USP19 and cardiac hypertrophy.