The IGFBP3 levels were very low or undetectable in human HCC samples compared with non‐neoplastic liver tissue which are 4‐ to 100‐fold higher than in HCC49 and IGFBP‐1 and IGFBP‐2 were also decreased in hepatoblastoma.50 This evidence concerns the gene IGFBP1 and hepatoblastoma.