Accordingly, actomyosin activity in melanoma has primarily been shown to be exerted via Rho-ROCK modulation of myosin activity (Herraiz et al., 2015; Pandya et al., 2017; Sanz-Moreno et al., 2008, 2011; Sanz-Moreno and Marshall, 2010) and is critical in modulating fast amoeboid invasion and metastasis (Sanz-Moreno et al., 2008; Sanz-Moreno and Marshall, 2010). Here, RHO is linked to melanoma.