In the intestine, tumor-associated myeloid cells produce IL-23 which affect Th17 cell polarization and the subsequent production of the cytokines IL-17A, IL-21, TNF-α and IL-6 which in turn, provide the pro-tumorigenic inflammatory response in CRC (De Simone et al., 2013; Long et al., 2017). The gene discussed is IL6; the disease is neoplasm.