An activated HSC can undergo senescence and become a senescence-associated secretory phenotype (SASP) that secretes tumor progression promoting cytokines (IL-6, IL-8), chemokines and proteases (matrix metalloproteinases, MMPs) which act to remodel the ECM and enhance inflammation (Rodier and Campisi, 2011; Rao and Jackson, 2016). Here, IL6 is linked to neoplasm.