In this capacity, it is plausible that anti-inflammatory therapies that reduce NF‐κB levels, such as non-acetylated salicylates (salsalate), as well as ibuprofen may be able to prevent the damage caused by unabated cytokine storms and hyperinflammatory states associated with COVID-19 (Fig. 4). This evidence concerns the gene NFKB1 and COVID-19.