Similarly, ZIP10 over-expression has been correlated to aggressiveness in renal cell carcinoma [36], metastatic breast cancer [35], gastric cancer [73] and it is one of the 7 zinc transporter genes upregulated in activated colon tumour cells [24], compatible with our proposed role for ZIP10 in cell division. This evidence concerns the gene SLC39A10 and hereditary clear cell renal cell carcinoma.