PTPN22 and Autoimmunity: HLA alleles (DRB1*0101 and DRB1*0404) and the PTPN22 rs2476601 (R620W) locus were associated with autoimmunity, while variants in IFIH1, PTPN22, SH2B3, BACH2 and CTLA4 were associated with occurrence of multiple autoantibodies [38].