Of note was PI3K family members: PIK3C2G, PIK3CA, PIK3CB, PIK3R4, Mucin family members: MUC1, MUC4 and MUC6 and other prostate cancer associated genes such as SMAD4, SOX9 and SPOP7,9,40,41. This evidence concerns the gene SMAD4 and Familial prostate cancer.