We validated three drugs (cabozantinib, clofarabine and vinblastine) in combination with a unique DNAJA1 inhibitor (116-9e) for synergy in the LNCaP cancer cell lines and confirmed omacetaxine mepesuccinate, idarubicin and sorafenib for antagonism (i.e. with reduced potency after DNAJA1 inhibition). This evidence concerns the gene DNAJA1 and cancer.