We observed that Kcnt2−/−Rag1−/− mice did not affect lymphocytes infiltration, colon injury, body weight loss and colitis scores compared with Kcnt2+/+Rag1−/− mice (Supplementary Fig. 4c–e), suggesting Kcnt2 has no influence on innate colitis induction. The gene discussed is KCNT2; the disease is colitis.