APOB and atherosclerosis: However, studies have shown that neutralization of MDA-apoB adducts with antibodies greatly enhances atherosclerosis regression in human apoB100 transgenic Ldlr−/− mice52,53 making it likely that the decreased atherosclerosis with 2-HOBA treatment is also due in part to decreased dicarbonyl modification of apoB within the atherosclerotic lesion.