ARHGDIA and cancer: The metastasis of cancer is associated with the expression of proteins such as α-enolase, stathmin, cofilin-1, Rho GDP-dissociation inhibitor 1 and thromboxane-A synthase, which serve as potential prognostic markers20–24 and may participate in the anti-metastatic actions of 20(S/R)-Rh2E2.