As shown in Supplementary Fig. S5, the genes encoding the metabolic enzymes for oxidation phosphorylation such as Atp5l, Cox4i1, Cox5a, Cox7a2, Ndufc2, Ndufs4, Sdhd, Uqcrq28 were significantly downregulated in 20(S)/(R)-Rh2E2-treated LLC-1 cancer cells, but not in normal cells. This evidence concerns the gene COX4I1 and cancer.