STMN1 and neoplasm: In addition, immunohistochemical analysis of tumor tissues collected from LLC-1 xenograft model treated with either 20(S)- or 20(R)-Rh2E2 showed similar expression signal, in which, the expression of α-enolase and stathmin were significantly suppressed after the treatment of 20(S)- or 20(R)-Rh2E2 (Fig. 2c).