KIF3A and Alzheimer disease: Our data provide a mechanistic basis for the AD disease susceptibility conferred by KIF3A SNPs rs11740584 and rs2299007 whereby the alternate alleles generate new CpG sites resulting in increased methylation and decreased expression of KIF3A. Skin methylation of the novel CpG sites created by rs11740584 and rs2299007 was associated with increased TEWL in individuals carrying the risk alleles.